Identification of CM1 as a Pathogenic Factor in In... Identification of CM1 as a Pathogenic Factor in Inflammatory Diseases and Cancer
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@article{
title={Identification of CM1 as a Pathogenic Factor in Inflammatory Diseases and Cancer},
author={배세연, 이나은, 공주명, 김항래, 황영일, 송영욱, 강재승, 이왕재, 김혜민, 유연실},
journal={Immune network},
year={2011},
volume={vol.11 no.3},
page={175-181}
}
title={Identification of CM1 as a Pathogenic Factor in Inflammatory Diseases and Cancer},
author={배세연, 이나은, 공주명, 김항래, 황영일, 송영욱, 강재승, 이왕재, 김혜민, 유연실},
journal={Immune network},
year={2011},
volume={vol.11 no.3},
page={175-181}
}
%0 Journal Article
%T Identification of CM1 as a Pathogenic Factor in Inflammatory Diseases and Cancer
%A 강재승
%A 공주명
%A 김항래
%A 김혜민
%A 배세연
%A 송영욱
%A 유연실
%A 이나은
%A 이왕재
%A 황영일
%J Immune network
%V vol.11 no.3
%P 175-181
%D 2011
%A 강재승
%A 공주명
%A 김항래
%A 김혜민
%A 배세연
%A 송영욱
%A 유연실
%A 이나은
%A 이왕재
%A 황영일
%J Immune network
%V vol.11 no.3
%P 175-181
%D 2011
강재승 .
"Identification of CM1 as a Pathogenic Factor in Inflammatory Diseases and Cancer"
Immune network
vol.11 no.3
(2011)
: 175-181
강재승
,
공주명
,
김항래
,
김혜민
,
배세연
,
송영욱
,
유연실
,
이나은
,
이왕재
,
황영일
(2011).
Identification of CM1 as a Pathogenic Factor in Inflammatory Diseases and Cancer Immune network, vol.11 no.3, 175-181.
Identification of CM1 as a Pathogenic Factor in Inflammatory Diseases and Cancer Immune network, vol.11 no.3, 175-181.
배세연, 이나은, 공주명, 김항래, 황영일, 송영욱, 강재승, 이왕재, 김혜민, 유연실.
"Identification of CM1 as a Pathogenic Factor in Inflammatory Diseases and Cancer"
Immune network
vol.11 no.3
(2011)
: 175-181
TY - JOUR
TI - Identification of CM1 as a Pathogenic Factor in Inflammatory Diseases and Cancer
AU - 강재승
AU - 공주명
AU - 김항래
AU - 김혜민
AU - 배세연
AU - 송영욱
AU - 유연실
AU - 이나은
AU - 이왕재
AU - 황영일
JO - Immune network
VL - vol.11 no.3
SP - 175
EP - 181
PY - 2011
외부LOD
| 저자 | 배세연, 이나은, 공주명, 김항래, 황영일, 송영욱, 강재승, 이왕재, 김혜민, 유연실 | ||
|---|---|---|---|
| 수록지 | Immune network vol.11 no.3 pp.175-181 | ||
| 발행사항 | The Korean Association of Immunobiologists | ||
| 발행년 | 2011 | ||
| UCI | G901:A-0003465746 공유 | ||
| DOI | http://dx.doi.org/10.4110/in.2011.11.3.175 | ||
| 언어 | eng | ||
| 주제어 | PGE2, Inflammatory responses, CM1, MMP-2/-9, ENO1 | ||
| 초록 |
Background: CM1 (centrocyte/-blast marker 1) was defined by a mAb against concavabalin-A (ConA) activated PBMC. It is expressed in germinal center of human tonsil and on the surface of activated PBMC as well as cancer cells. Recently, increased productions of pro-inflammatory mediators were detected from activated PBMC by CM1 ligation. Methods: However, there is a limitation to explain the exact role of CM1 on inflammation and its related mechanisms, since the identity of CM1 is still not clarified. In our previous study, we have already confirmed that soluble form of CM1 was produced by Raji. Therefore, we performed Q-TOF analysis after immunoprecipitation of concentrated Raji culture supernatant using anti-CM1 mAbs. Results: As a result, we found that CM1 is identical to enolase-1(ENO1), a glycolytic enzyme, and we confirmed that results by silencing ENO1 using siRNA. It was also confirmed through competition assay between anti-CM1 and anti-ENO1 mAbs. Finally, we investigated the possible role of CM1 in inflammatory response and cancer. The ligation of CM1 on Raji cells with anti-CM1 mAbs induces the extensive production of prostaglandin |
||
| 목차 | Contents Identification of CM1 as a Pathogenic Factor in Inflammatory Diseases and Cancer / 배세연 ; 이나은 ; 공주명 ; 김항래 ; 황영일 ; 송영욱 ; 강재승 ; 이왕재 ; 김혜민 ; 유연실 1 [요약] 1 INTRODUCTION 1 MATERIALS AND METHODS 2 RESULTS 3 DISCUSSION 5 REFERENCES 7 |
||
| 원문보기 | KISTI 원문 | ||